STUDY OF TOXICITY INDICATORS OF THE NEW ANTI-MASTI DRUG BASED ON IODINE COMPOUNDS
Abstract
Mastitis of cows causes significant damage to agriculture. Mastitis causes a decrease in the quality and safety of milk. The development of the latest drugs for the treatment of cows from mastitis is one of the priority tasks of veterinary medicine. One of the promising directions for the creation of anti-mastitis drugs is the creation of drugs based on iodine compounds, which prevents the emergence of resistance in microorganisms. This article presents data on the study of the toxicity of an experimental antimastitis drug for use in cows in the postpartum period. The research was conducted on the basis of the laboratory “Innovative technologies and safety and quality of livestock products” and “Veterinary pharmacy” of the department of veterinary expertise, microbiology, zoohygiene and safety and quality of livestock products of the Faculty of Veterinary Medicine of the Sumy National Agrarian University. The study of the new antimastitis drug was carried out according to the methods outlined in the manual “Preclinical studies of veterinary medicinal products”. At the first stage of the drug’s toxicity study, its toxic effect on the body of animals was studied under conditions of short-term exposure, with data on lethal doses and concentrations obtained. With a single administration of the drug, the parameters of toxicity and symptoms of acute poisoning were determined. At the second stage of the study, the chronic effect of the drug on homeostasis indicators of experimental rats was determined. Data are presented on the calculation of the parameters of the lethal dose of sulfur on white rats using calculations by two methods of H. Pershin and H. Kerber. Data on determining chronic toxicity indicators of a new experimental drug intended for the treatment and prevention of mastitis in cows in the postpartum period are also given. When calculating the average lethal dose of an experimental antimastitis drug using the methods of H. Pershin and H. Kerber, the same results were obtained – 1670 mg/kg of weight. As a result of research, it was established that the drug belongs to the third class of danger (moderately dangerous compounds) in terms of toxicity parameters. Development of a new drug for combating mastitis in the postpartum period, which provides effective control of the microflora that causes mastitis in cattle. The use of this drug will ensure effective prevention and treatment of bovine mastitis in the postpartum period.
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