СТІЙКІСТЬ ДО АНТИБІОТИКІВ – ГЛОБАЛЬНА ПРОБЛЕМА В ІНДИКІВНИЦТВІ
Ключові слова:
птахівництво, антибіотикорезистентність, патогенна мікрофлора, протимікробні препарати, стійкість, чутливість
Анотація
Розвиток і поширення явища стійкості до антибіотиків стало серйозною причиною для занепокоєння. За кілька останніх десятиліть не було вироблено ніяких великих нових типів антибіотиків, і майже всі відомі антибіотики все більше втрачають свою активність проти патогенних мікроорганізмів. Розвиток і поширення резистентності до антибіотиків поступово обмежує можливості лікування та профілактики більшості бактеріальних збудників, загрожуючи основним компонентам сучасної гуманної та ветеринарної медицини. Ненормоване використання антибіотиків у сфері лікування людей, тварин, птиці і навколишнього середовища, а також поширення резистентних бактерій і генів резистентності серед цих секторів і в усьому світі є факторами, що сприяють цьому. Антибіотики можуть потрапляти в навколишнє середовище з різних джерел, включаючи відходи людини, ветеринарні відходи та відходи тваринництва. Метою нашої роботи було визначити біохімічні властивості виділених культур з патматеріалу (трупів індиків різних вікових груп), та дослідити чутливість культур до антибактеріальних препаратів. Дослідження проводились на базі кафедри ветеринарно-санітарного інспектування, мікробіології, гігієни та патологічної анатомії. В дослідженнях використовували: бактеріологічний, патологоанатомічний, біохімічний методи. У статті наведені результати біохімічних властивостей мікроорганізмів групи E. coli та їх чутливість до найбільш вживаних у ветеринарній практиці препаратів. Виділені культури були оксидазонеативними, утворювали індол, не утворювали сірководень, давали негативну реакцію Фогеса-Проскауера, не утилізували цитрат. За морфологічними властивостями це були грамнегативні палички, продовгуватої форми, які розташовувалися в мазках поодиноко або попарно. При визначенні чутливості виділених штамів до антибактеріальних препаратів ми виявили, що 26,3 % виділених культур були резистентними до найпопулярніших антимікробних препаратів у ветеринарній практиці. Виділені культури E. coli найбільш резистентними були до групи антибактеріальних препаратів пеніцилінового ряду (87,7%), групи поліміксини (83,9 %) і макролідів (25,7 %).
Посилання
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2. Amin, M. B., Sraboni, A. S., Hossain, M. I., Roy, S., Mozmader, T. A. U., Unicomb, L., Rousham, E. K., & Islam, M. A. (2020). Occurrence and genetic characteristics of mcr-1-positive colistin-resistant E. coli from poultry environments in Bangladesh. Journal of global antimicrobial resistance, 22, 546–552. https://doi.org/10.1016/j.jgar.2020.03.028
3. Bahram, M., Hildebrand, F., Forslund, S. K., Anderson, J. L., Soudzilovskaia, N. A., Bodegom, P. M., Bengtsson-Palme, J., Anslan, S., Coelho, L. P., Harend, H., Huerta-Cepas, J., Medema, M. H., Maltz, M. R., Mundra, S., Olsson, P. A., Pent, M., Põlme, S., Sunagawa, S., Ryberg, M., Tedersoo, L., … Bork, P. (2018). Structure and function of the global topsoil microbiome. Nature, 560(7717), 233–237. https://doi.org/10.1038/s41586-018-0386-6
4. Bai, H., He, L. Y., Wu, D. L., Gao, F. Z., Zhang, M., Zou, H. Y., ... & Ying, G. G. (2022). Spread of airborne antibiotic resistance from animal farms to the environment: dispersal pattern and exposure risk. Environment international, 158, 106927.
5. Beytur, A., Yakupogullari, Y., Oguz, F., Otlu, B., & Kaysadu, H. (2014). Oral amoxicillin-clavulanic Acid treatment in urinary tract infections caused by extended-spectrum Beta-lactamase-producing organisms. Jundishapur journal of microbiology, 8(1), e13792. https://doi.org/10.5812/jjm.13792
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9. Duan, M., Gu, J., Wang, X., Li, Y., Zhang, R., Hu, T., & Zhou, B. (2019). Factors that affect the occurrence and distribution of antibiotic resistance genes in soils from livestock and poultry farms. Ecotoxicology and environmental safety, 180, 114–122. https://doi.org/10.1016/j.ecoenv.2019.05.005
10. Fotina T.I. (2016). Naiposhyrenishi khvoroby indykiv [The most common diseases of turkeys]. Zhurnal «Ptakhivnytstvo», 3(45), 88-90. [in Ukrainian].
11. Garcia-Migura, L., Hendriksen, R. S., Fraile, L., & Aarestrup, F. M. (2014). Antimicrobial resistance of zoonotic and commensal bacteria in Europe: the missing link between consumption and resistance in veterinary medicine. Veterinary microbiology, 170(1-2), 1–9. https://doi.org/10.1016/j.vetmic.2014.01.013
12. Gaucher, M. L., Perron, G. G., Arsenault, J., Letellier, A., Boulianne, M., & Quessy, S. (2017). Recurring Necrotic Enteritis Outbreaks in Commercial Broiler Chicken Flocks Strongly Influence Toxin Gene Carriage and Species Richness in the Resident Clostridium perfringens Population. Frontiers in microbiology, 8, 881. https://doi.org/10.3389/fmicb.2017.00881
13. Giguère, S. (2013). Lincosamides, pleuromutilins, and streptogramins. Antimicrobial therapy in veterinary medicine, 199-210.
14. Giguère, S. (2013). Macrolides, azalides, and ketolides. Antimicrobial therapy in veterinary medicine, 211-231.
15. Harbarth, S., Balkhy, H. H., Goossens, H., Jarlier, V., Kluytmans, J., Laxminarayan, R., Saam, M., Van Belkum, A., Pittet, D., & for the World Healthcare-Associated Infections Resistance Forum participants (2015). Antimicrobial resistance: one world, one fight!. Antimicrobial Resistance and Infection Control, 4, 49. https://doi.org/10.1186/s13756-015-0091-2
16. He, Y., Yuan, Q., Mathieu, J., Stadler, L., Senehi, N., Sun, R., & Alvarez, P. J. (2020). Antibiotic resistance genes from livestock waste: occurrence, dissemination, and treatment. NPJ Clean Water, 3(1), 4.
17. Hendriksen, R. S., Munk, P., Njage, P., van Bunnik, B., McNally, L., Lukjancenko, O., Röder, T., Nieuwenhuijse, D., Pedersen, S. K., Kjeldgaard, J., Kaas, R. S., Clausen, P. T. L. C., Vogt, J. K., Leekitcharoenphon, P., van de Schans, M. G. M., Zuidema, T., de Roda Husman, A. M., Rasmussen, S., Petersen, B., Global Sewage Surveillance project consortium, … Aarestrup, F. M. (2019). Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. Nature communications, 10(1), 1124. https://doi.org/10.1038/s41467-019-08853-3
18. Hutchings, M. I., Truman, A. W., & Wilkinson, B. (2019). Antibiotics: past, present and future. Current opinion in microbiology, 51, 72–80. https://doi.org/10.1016/j.mib.2019.10.008
19. Jiang, X., Ellabaan, M. M. H., Charusanti, P., Munck, C., Blin, K., Tong, Y., Weber, T., Sommer, M. O. A., & Lee, S. Y. (2017). Dissemination of antibiotic resistance genes from antibiotic producers to pathogens. Nature communications, 8, 15784. https://doi.org/10.1038/ncomms15784
20. Kaper, J. B., Nataro, J. P., & Mobley, H. L. (2004). Pathogenic Escherichia coli. Nature reviews. Microbiology, 2(2), 123–140. https://doi.org/10.1038/nrmicro818
21. Katz, L., & Baltz, R. H. (2016). Natural product discovery: past, present, and future. Journal of industrial microbiology & biotechnology, 43(2-3), 155–176. https://doi.org/10.1007/s10295-015-1723-5
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Опубліковано
2025-03-14
Як цитувати
Марушко, Д. В., & Петров, Р. В. (2025). СТІЙКІСТЬ ДО АНТИБІОТИКІВ – ГЛОБАЛЬНА ПРОБЛЕМА В ІНДИКІВНИЦТВІ. Вісник Сумського національного аграрного університету. Серія: Ветеринарна медицина, (4(67), 63-69. https://doi.org/10.32782/bsnau.vet.2024.4.9
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